Ron Prince was probably never going to last long in Piscataway, mostly due to the fact that he has had a wandering eye ever since he was ousted at Kansas State. He's been back and forth from the NFL and college ranks, and according to a various media reports, Prince may be making a play for the pros once again.
Based on the results this past season, losing Prince isn't the biggest deal in the world. With Rob Spence gone and Prince taking over QB coach duties, it's possible that things could have improved. But the Rutgers offense this year was highly inconsistent, and it's more likely that the Scarlet Knights would have improved only marginally.
The biggest hit would be to recruiting. With so much turmoil going on with the staff, Coach Flood certainly asked Prince to make some recruiting trips, plus a lot of prospects like to know what type of offense they will be running. The Star-Ledger reports that Brian Angelichio could be a candidate to replace Prince. I find this move to be unlikely, considering he's been a longtime tight ends coach and not much else. The only reason to make him OC would be for recruiting purposes, but the offensive coordinator position is too important to sacrifice simply for recruiting.
Another candidate mentioned is Andy Cohen, who is the Lehigh head coach. Cohen has a 59-33 overall record as Lehigh head coach with three conference titles from 2006, 2010, and 2011 (undefeated conference records in '10 & '11). Don Treadwell might still be looking for a job as well, and has B1G experience, making him a good candidate for both offensive coordinator and QB coach.
This is, without a doubt, terrible timing for the Scarlet Knights. NSD is right around the corner and the current class has been through so much already. Flood needs to make moves now.